2022 Webinar: HBV DNA Integration: Mechanisms, Pathogenesis and Clinical Relevance in Liver Disease Progression and Functional Cure-HBV DNA Integration: Mechanisms, Pathogenesis and Clinical Relevance in Liver Disease Progression and Functional Cure

HBV DNA Integration: Mechanisms, Pathogenesis and Clinical Relevance in Liver Disease Progression and Functional Cure

Video Transcription

Video Summary

The webinar focused on HPV DNA integration and its role in hepatitis B virus (HBV) infection and liver disease progression. The speakers discussed the basic virology of HPV DNA integration, its clinical relevance, and potential therapeutic implications. They emphasized the importance of early treatment in preventing HPV integration and reducing the risk of hepatocarcinogenesis. Integration was found to be a random event that occurs early after infection and throughout chronic infection. It results in replication-defective HBV DNA that can still express viral proteins and contribute to disease pathogenesis. The speakers also highlighted the need for further research to understand the timing and impact of integration events during different phases of chronic HBV infection. They also discussed the potential role of integration in HCC development and the importance of considering integration-driven viral protein expression in the diagnosis and treatment of chronic HBV infection. Overall, the webinar provided insights into the role of HPV DNA integration in liver disease progression and highlighted the need for early intervention and new therapeutic strategies to prevent integration and promote functional cure.

Keywords

HPV DNA integration

hepatitis B virus

HBV infection

liver disease progression

virology

clinical relevance

therapeutic implications

early treatment

hepatocarcinogenesis

replication-defective HBV DNA