The goal of this webinar is to review mechanisms of HBV DNA integration in the context of potential clinical relevance including HCC, clinical monitoring, treatment and emerging therapeutics towards a functional cure. Some questions to be explored re: HBV DNA integration in this webinar: What is it? How/when does it happen? What is its potential impact in liver disease pathogenesis and clinical outcome (e.g. HCC)? What are potential impact of HBV DNA integration on timing of treatment initiation, clinical monitoring and novel therapeutic development?