TLM 2022 - State-of-the-Art Lectures

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A collection of lectures covering the state of the art in liver medicine, originally presented at The Liver Meeting 2022 in Washington, D.C.

Lectures include: 

  • Thomas E. Starzl Transplant Surgery State-of-the-Art Lecture, Normothermic Liver Perfusion to Improve Early Allograft Function
  • Leon Schiff State-of-the-Art Lecture, The evolution of disease modeling in NAFLD
  • Hans Popper State-of-the-Art Lecture, Human Organoids Toward Precision Hepatology
  • Hyman J. Zimmerman Hepatotoxicity State-of-the-Art Lecture, Mechanisms of Drug-induced Liver Injury

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Thomas E. Starzl Transplant Surgery State-of-the-Art Lecture
Open to view video.  |  30 minutes
Open to view video.  |  30 minutes Presented by Dr. Peter J. Friend, Nuffield Department of Surgical Sciences, University of Oxford This presentation will summarize the evidence relating to the use of normothermic machine perfusion of the liver, and will address the future applications of this technology in liver transplantation.
Leon Schiff State-of-the-Art Lecture
Open to view video.  |  33 minutes
Open to view video.  |  33 minutes Presented by Dr. Jacquelyn J. Maher, Department of Medicine, University of California San Francisco The objective of this program is to provide learners with a longitudinal perspective of disease modeling in NAFLD over the last 20 years. Emphasis will be placed on the shift from animal human models, the latter taking advantage of new research technologies. The advantages and limitations of each will be discussed.
Hans Popper State-of-the-Art Lecture
Open to view video.  |  40 minutes
Open to view video.  |  40 minutes Presented by Dr. Takanori Takebe, MD, Pediatrics, Cincinnati Children's Hospital Medical Center The goal of this program is to propose integrative pre-clinical research concept for human NAFLD/NASH, combining patients’ and engineered human tissues using emerging technologies such as induced pluripotency, organoids, gene editing and comprehensive genomics. By introducing population-based organoid system, this investigative strategy may open the door to the studies of pleiotropic factors, potentially transforming the future of precision hepatology.
Hyman J. Zimmerman Hepatotoxicity State-of-the-Art Lecture
Open to view video.  |  30 minutes
Open to view video.  |  30 minutes Presented by Dr. Jack Uetrecht, Pharmacy and Medicine, University of Toronto The goal of the session is to critically review mechanistic hypotheses of idiosyncratic drug-induced liver injury (iDILI). A better mechanistic understanding of iDILI can be used to improve drug safety as indicated in the Objectives below.