Liver Cell Biology in Hepatic Diseases SIG: Organelle Trafficking and Lipid Droplets Biology

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Recorded On: 11/09/2018

This program discusses different, yet related, basic molecular mechanisms of hepatic damage and inflammation fundamental for the development of various types of liver diseases. Discussions will cover the mechanisms for vesicle formation and  endocytosis, how secretion of exosomes occurs upon inflammasome activation, the impact of immune cell-derived vesicles on fibrosis and the process of collagen secretion. The second part of the program focuses on novel signaling pathways  involved in disease resolution.

This program will provide an excellent opportunity to learn the basic molecular mechanisms of hepatic damage and inflammation fundamental for the development of various types of liver diseases.

Mark McNiven

Ann Wozniak

Yasuko Iwakiri

Xin Chen

Z. Gordon Jiang

Richard Green

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Session I: Organelle Trafficking
Membrane Trafficking in Lipid Droplet-Mitochondrial Dynamics
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Open to view video. Presenter: Mark McNiven
Mechanisms linking inflammasome activation to exosomal cargo loading and secretion
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Open to view video. Presenter: Ann Wozniak
Immune cell extracellular vesicles and portal tract fibrosis
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Open to view video. Presenter: Yasuko Iwakiri
Panel Discussion /Q&A
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Open to view video.
Session II: Lipid Droplets Biology
Functional role of de novo lipogenesis in oncogene induced hepatocarcinogenesis
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Open to view video. Presenter: Xin Chen
Altered lipoprotein metabolism in nonalcoholic and alcoholic fatty liver diseases
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Open to view video. Presenter: Z. Gordon Jiang
IRE1-Alpha/XBP1 in Steatohepatitis
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Open to view video. Presenter: Richard M. Green
Panel Discussion /Q&A
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Open to view video.
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