Hepatobiliary Neoplasia SIG: HCV Therapy and HCC

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Recorded On: 10/23/2017

This program provides a timely review of the mechanistic and clinical information relevant to HCC occurring in HCV by addressing the relevance of the problem and treatment effects. The program will also discuss key basic concepts with relevance to HCC in HCV.

Gregory J. Gores

Gregory J. Gores, M.D. is a quintessential, senior academician; a “quadruple threat” with contributions to research, clinical practice, education, and leadership.  His research contributions include sustained federal funding (greater than 30 years), over 690 publications, an H-index of 130, and over 50,000 citations (Scopus data base). Based on these accomplishments, he was appointed as a Distinguished Mayo Investigator. His clinical focus on hepatobiliary neoplasia has led to novel protocols regarding liver transplantation for cholangiocarcinoma.  Educational activities include mentoring over 80 fellows, and directing a liver transplant fellowship program. These activities have been recognized by receipt of an American Gastroenterological Association Mentorship Award. Extramural leadership positions include past presidency of the American Association for the Study of Liver Disease (AASLD) and the International Liver Cancer Association, and a past Councilor of the American Gastroenterological Association (AGA). Intramural positions include serving as past Chair of the Gastroenterology and Hepatology Division at Mayo Clinic Rochester, and current Executive Dean for Research across the Mayo enterprise. His stature and accomplishments were recently recognized by prestigious awards from the Mayo Alumni Association, the AASLD, the German Society of Gastroenterology, and the Canadian Liver Foundation and Canadian Association for the Study of Liver.

Augusto Villanueva

Augusto Villanueva is Assistant Professor in the Liver Cancer Program (Icahn School of Medicine at Mount Sinai, New York). He received his medical degree from the University of Santiago de Compostela (Spain), and he is board certified in Gastroenterology and Hepatology (Spain). In 2005, he joined the Division of Liver Diseases at Mount Sinai Hospital (New York) as a research fellow and was involved in different translational research projects focused on the molecular pathogenesis of hepatocellular carcinoma (HCC). In 2008, he obtained his PhD and received the Sheila Sherlock Fellowship from EASL to join the Liver Cancer Translational Research Laboratory of the BCLC Group, Barcelona (Spain). In 2010, he became the Scientific Manager of the HEPTROMIC consortium, a research initiative funded by the European Commission aimed at identifying genomic prognostic predictors and oncogenic drivers in HCC.

In 2013, he joined the Institute of Liver Studies at King’s College (London), as a Senior Lecturer and Consultant Hepatologist where he served as co-leader of the HCC Clinic and Multidisciplinary Tumor Board. In 2014, he started his position at the Icahn School of Medicine at Mount Sinai with the goal of developing novel minimally invasive biomarkers using liquid biopsy and studying the impact of intratumor heterogeneity in HCC. He has more than 100 publications (10,000 citations, H-index 44) including articles in N Engl J MedNat GenetNat BiotechGastroenterology, HEPATOLOGY, J HepatolJ Clin InvestOncogene, etc. He wrote more than fifteen book chapters and edited a book on resistance to targeted therapies in HCC. He served as Associate Editor for J Hepatol (2014-2019) and Liver Cancer (2012-present).

Hashem B. El-Serag

Nathalie G. Carrie

Michael D. Leise

Dr. Leise finished his internal medicine residency, chief residency, Gastroenterology and Transplant Hepatology fellowships at Mayo Clinic, Rochester.  He is an Assistant Professor of Medicine with research interests in Hepatitis C, hepatic encephalopathy, and liver transplant outcomes.

Maria Reig

Amit G. Singal

Dr. Singal is a Professor of Internal Medicine, Chief of Hepatology, and Medical Director of the Liver Tumor Program at UT Southwestern Medical Center in Dallas, TX. He has obtained state, DOD and NIH funding to examine the HCC care continuum, ranging from HCC prevention to screening and early detection to treatment and survivorship. Dr. Singal has published over 150 scientific papers regarding HCC screening and treatment. For his work, he has been awarded the David Bruton Professorship in Clinical Cancer Research and Blue Faery Award for Excellence in Liver Cancer Research.

Laura M. Kulik

I am a Professor of Medicine in the Division of Gastroenterology and Hepatology, and am Certified in both Gastroenterology and Hepatology and in Transplant Hepatology. My major clinical research focus is on the therapy and diagnosis of hepatocellular carcinoma. I work in a muliti-disciplinary medical/radiologic/surgical Liver Tumor clinic, and am involved in the recruitment of patients with HCC into clinical or pathologic trials. My major interest is on loco-regional therapy for HCC, both as a primary therapy and as a bridge to liver transplantation, including 90Yttrium radiotherapy and TACE.

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