Clinical Research Workshop
Recorded On: 10/20/2017
With the rising epidemic of NASH and NASH-related end stage liver disease, there is a pressing need to better define the pathogenesis of NASH, identify meaningful biomarkers and effective treatments. This workshop aims to bring together investigators from bench to bedside to identify the best methods of collaboration at the translational level, determine how to define meaningful endpoints, and work in teams across disciplines, institutions and with pharma to address this epidemic.
Anna Mae Diehl
Anna Mae Diehl, MD, FAASLD is currently the Florence McAlister Professor of Medicine at Duke University. She is a physician scientist and academic hepatologist. Her lab-based research activities focus on basic mechanisms of liver repair and complement her translational/clinical research programs in alcoholic- and nonalcoholic fatty liver disease. In the past two years, Dr. Diehl she has co-authored ten peer-reviewed manuscripts on these topics.
Her basic research program has enjoyed uninterrupted NIH RO1 support since 1990 and she has been the Principal Investigator for the NASH CRN UO1 clinical research program at Duke since its inception over 15 years ago. Dr. Diehl’s research contributions to the fields of regenerative medicine, alcohol-related liver disease and NAFLD have been acknowledged by election for membership in the American Society for Clinical Investigation, Interurban Clinical Club, Association of Academic Professors and Johns Hopkins University Society of Scholars, as well as awards such as an NIH/NIAAA Merit Award, the NIAAA Mendelson Award, the Duke Distinguished Faculty Award, and the AASLD Distinguished Scientific Achievement Award.
Dr. Diehl has been an associate editor/editorial board member for major journals such as HEPATOLOGY, Gastroenterology, GUT, The American Journal of Physiology, The Journal of Clinical Investigation, Nature Reviews, and eLife. In addition, she has served as a standing member of several NIH study sections and scientific advisory councils for NIDDK, NCI, NIAAA, the American Liver Foundation, the Alcoholic Beverage Medical Research Foundation, NIDDK Digestive Disease Centers at Baylor, USC and U Pittsburgh, and NIAAA Alcohol Research Centers at U Louisville and the Cleveland Clinic.
Manal F. Abdelmalek
Manal F.Abdelmalek, MD, MPH, FAASLD is a tenured Professor of Medicine in the Divisionof Gastroenterology and Hepatology and Director of the Nonalcoholic Fatty LiverDisease (NAFLD) Clinical Research Program at Duke University. Since firstreporting on nonalcoholic steatohepatitis (NASH) as a cause of cryptogeniccirrhosis nearly 25 years ago, her clinical and research area of interest hasfocused on NAFLD / NASH, associated risk factors for disease acquisition andprogression and the discovery of novel approaches to treatment. She has expertise in clinical-translationalresearch, the design and conduct of clinical trials, includinginvestigator-initiated, industry sponsored and NIH-funded clinical studies evaluatingnew therapies and biomarkers for NAFLD and NASH. She collaborates extensively to translate newcompounds to first-in-man clinical studies and translate clinic-to-bench andbench-to-clinic research to define pathogenic mechanisms underlying NAFLD acquisitionand progression and new compounds into first-in-man clinical studies. She is the lead Principal Investigator onseveral multicenter global studies, a member of the AASLD Global Outreach andEngagement Committee and past member of the AASLD Clinical Research Committee. Dr.Abdelmalek is a Fellow of American College of Physicians, American College ofGastroenterology and American Association for the Study of Liver Disease. She is a standing member of NASH ClinicalResearch Network (NASH CRN) for the past 15 years, has published more than 200manuscripts and currently serves on the Editorial Board of HEPATOLOGY, theofficial journal of the AASLD.
