Basic Research Workshop
Recorded On: 11/13/2016
This workshop will focus on how inducible pluripotent stem cells (iPSCs) can be used to produce liver cells and organoids. These are exciting new tools for experimental hepatology and hold great promise for clinical hepatology. The generation of iPSC-derived liver cells enables studies of the pathophysiology of several human conditions and to explore the effects of new drugs and treatment following a personalized medicine approach. iPSCs can also give rise to multicellular liver organoids with the potential to recapitulate the cellular ecosystem of a human liver, maintain the inter-cellular relationships, and reproduce models of liver disease as experimental models and potential organ-replacement strategies.
Mario Strazzabosco MD, PhD, is Professor of Medicine at Yale University, CT. He is Director of the Yale Liver Cancer Programat Smilow Hospital and Co-Director of the Yale Liver Center. Dr. Strazzabosco is the principal investigator in a number of research projects in the field of hepatology, and health care management and directs an NIH-sponsored Lab at the Yale University School of Medicine. His main current research interests relate to the pathophysiology of biliary tract diseases, biology of liver repair, liver cancer and health care management. He has received numerous awards and is a Fellow of the American College of Gastroenterology (FACG) a Fellow of the European Board of Surgery (transplant) (FEBS) and a Fellow of the American Association for the Study of Liver Disease (FAASLD).