Acute on Chronic Liver Failure SIG: The Role of Infection in the Development of ACLF
Recorded On: 11/09/2018
Bacterial infections are common in patients with advanced cirrhosis — partly related to altered microbiota, partly related to increased bacterial translocation across the gut wall and partly related to compromised immune function of these patients. When bacterial infection occurs, the heightened inflammatory reaction that follows predisposes these patients to altered hemodynamics and direct tissue damage. Therefore, these patients are prone to develop organ failure and ACLF when bacterial infection occurs. This program discusses recent findings on how altered microbiota and inflammation are involved in the pathogenesis of organ failure and ACLF in cirrhosis. Approach to treatment of various organ failures as well as preventive measures will be discussed.
Jasmohan S. Bajaj
Dr. Garcia-Tsao is Professor of Medicine, Chief of Digestive Diseases and Program Director of the Hepatitis C Resource Center at Veteran’s Administration-Connecticut Healthcare System, as well as Director of Clinical and Translational Core at Yale Liver Center. She is a past president of AASLD. She received her M.D. and training at Universidad Nacional Autónoma de Mexico. Her primary research focus is on clinical research which focuses on cirrhosis and its complications, and she also is involved in the study of bacterial infections in cirrhosis, a complication that is often overlooked.