OasisLMS

Hepatocyte growth factor receptor (MET) and epidermal growth factor receptor (EGFR), are considered essential for liver regeneration as their combined signaling disruption leads to a complete elimination of regeneration after partial hepatectomy (PHx). However, roles of these growth factor receptors in APAP-induced liver injury (AILI), the clinically-relevant model of acute liver failure, remain underexplored. Unlike PHx in a normal healthy liver, AILI is complicated by presence of massive liver injury and inflammation that intricately govern the regenerative response. This presentation will discuss the divergent roles of EGFR and MET in acute liver injury after APAP overdose, as opposed to their conventionally known and functionally similar roles in hepatocyte proliferation. In contrast to their similar roles in liver regeneration, MET directly suppresses and, paradoxically, EGFR aggravates acute liver injury in the AILI model.

This activity originally aired on October 9, 2025.

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