The Liver Meeting® 2018 ePosters: NAFLD and NASH
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LB-22: NGM282 Maintains a Durable Off-Treatment Response on Hepatic Steatosis, Inflammation and Fibrogenesis in Patients with Biopsy-Confirmed Nonalcoholic Steatohepatitis: Results of a Multi-Center Phase 2 Dose-Finding StudyAuthors: Stephen Rossi, Angelo ParedesYou must log in to access content.
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730: YH25724, a Novel Long-Acting GLP-1/FGF21 Dual Agonist, Exhibits Marked Anti-Fibrotic Effects in a Rat Model of Established Thioacetamide-Induced Liver FibrosisAuthors: Junhwan Kim, Tae Wang Kim, Han Na Hong, Hyun Ho Choi, Do-Hoon Kim, Ji-Eun Yang, Da-Na Jeong, Mi Kyeong Ju, Minji Seo, Su Kyung Kim, Ju-Young Park, Byung Hyun Choi, Jong Gyun Kim, Kyoung Kyu Ahn, Han-Joo Kim, Se-Woong Oh, Soongyu Choi, Vlad RatziuYou must log in to access content.
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731: Economic Burden of Progression to Cirrhosis in Patients with Non-Alcoholic Steatohepatitis (NASH) in the United StatesAuthors: Dhaval Patil, Ying Qiu, Tzuyung Kou, Joel Myers, Aditya Nandal, Leah BurnsYou must log in to access content.
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734: The FASN Inhibitor, TVB3664, Ameliorates Nash in a Murine ModelAuthors: Dipankar Bhattacharya, Gregory Duke, Brittany Allen, Maria Cecilia Ybanez, George Kemble, Scott FriedmanYou must log in to access content.
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738: Aramchol Downregulates SCD1 and Induces Pparg in Hepatic Stellate Cells to Attenuate Cellular Activation and FibrogenesisAuthors: Jose Mato, Brittany Allen, Amanda Craig, David Fernandez-Ramos, Fernando Lopitz-Otsoa, Liat Hayardeny, Augusto Villanueva, Scott FriedmanYou must log in to access content.
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745: The MetAP2 Inhibitor, Zgn-1061, Improves Metabolic Parameters and Hepatic Pathology in Mouse Models of Diabetes and Nonalcoholic Steatohepatitis or Hepatocellular CarcinomaAuthors: Bryan Burkey, Martin Illemann, Sanne Veidal, Michael Feigh, Michael Briggs, Dipti Deshpande, James Vath, Thomas HughesYou must log in to access content.
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747: Polydatin Attenuates Diet-Induced Nonalcoholic Steatohepatitis and Fibrosis in MiceAuthors: Tian Lan, Rui Li, Hui LI, Sishan Yan, Jiaxin Lin, Genshu Wang, Ying ChenYou must log in to access content.
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749: High-Sensitivity C-Reactive Protein Reductions in Subjects with Elevated Alanine Aminotransferase Receiving Semaglutide for Treatment of Obesity in a Phase 2 TrialAuthors: Philip Newsome, Vlad Ratziu, Salvatore Calanna, Morten Hansen, Martin Linder, Sven FrancqueYou must log in to access content.
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750: Treatment of Fatzopco Nash Mouse Model with Msdc-0602K and LiraglutideAuthors: Jerry Colca, Katheryn Coy, Anita Teepol, Guodong Zhang, Melissa Bass, Charles Jackson, Laura HealyYou must log in to access content.
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753: Differential Risk of Cardiovascular Outcome in Advanced Nash Patients with Type 2 Diabetes Mellitus (T2DM) - a Retrospective Analysis of a Large United States Insurance Claims DatabaseAuthors: Tzuyung Kou, Dhaval Patil, Aditya Nandal, Ying Qiu, Leah BurnsYou must log in to access content.
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755A: Using Quantitative Systems Pharmacology Modeling to Understand the Effects of Acetyl CoA Carboxylase (ACC) Inhibition on Liver and Plasma Triglycerides in a Simulated PopulationAuthors: Scott Siler, Grant Generaux, Brett Howell, Adrian Ray, Mani Subramanian, Robert Myers, Paul WatkinsYou must log in to access content.
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1258: Reduction in D-Lactate Correlates with Reductions in Liver Fat and De Novo Lipogenesis (DNL) after Fructose Restriction in Obese Children and Adolescents: A New Link between Fructose and Non-Alcoholic Fatty Liver Disease (NAFLD)?Authors: Alejandro Gugliucci, Yasmin Bains, Russell Caccavello, Ayca Erkin-Cakmak, Mike Wen, Kathleen Mulligan, Robert Lustig, Jean Schwarz, Susan NoworolskiYou must log in to access content.
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1267: Protease-Activated Nanosensors for Noininvasive Monitoring of NashAuthors: Andrew Warren, Sophie Cazanave, Eric Huang, Gabe Kwong, Jay Luther, Raymond Chung, Kathleen Corey, Sangeeta Bhatia, Elan Witkowski, Matthew HutterYou must log in to access content.
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1268: Deletion of FXR in Myeloid Cells Exacerbates Inflammation but Limits Fibrosis in a Murine Model of Non-Alcoholic Fatty Liver DiseaseAuthors: Rachel McMahan, Cara Porsche, David Orlicky, Moshe Levi, Lucy Golden-Mason, Hugo RosenYou must log in to access content.
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1270: Transcriptomic Analysis of Macrophages Treated with Sphingosine 1-Phosphate Identifies Mir-1249-5p Participating in Monocyte Chemoattractant Protein-1 Expression in Non-Alcoholic SteatohepatitisAuthor: Xiaofang Ji, Lei Tian, Na Chang, Le Yang, Xianghui Duan, Lin Yang, Liying LiYou must log in to access content.
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1279: Safety, Pharmacokinetics, and Immunogenicity of BMS-986263/ND-L02-s0201 in Healthy Japanese and Non-Japanese ParticipantsAuthors: Benjamin Soule, Edgar Charles, Giridhar Tirucherai, Frans Roodt, Uma Kavita, Ratna Revankar, Rose ChristianYou must log in to access content.
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1286: THE LINKS BETWEEN TRANSCRIPTION AND HISTOLOGY IN NONALCOHOLIC FATTY LIVER DISEASE AND THE DEVELOPMENT OF A GENE-LEVEL SEVERITY SCOREAuthors: Steve Hoang, Abdul Oseini, Robert Vincent, Ryan Feaver, Banumathi Cole, Robert Figler, Mark Lawson, Amon Asgharpour, Faridoddin Mirshahi, Brian Wamhoff, Arun Sanyal, Nathan Day, Justin TaylorYou must log in to access content.
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1290: Deletion of IL-4 Receptor Alpha on Macrophages Attenuates Inflammation and Fibrosis in Murine Nonalcoholic Steatohepatitis (NASH)Authors: Muhammad Ashfaq Khan, Misbah Aslam, Marcel Senkowski, Shih Weng, Detlef SchuppanYou must log in to access content.
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1291: Hepatocyte-Specific Depletion of Nuclear Membrane Proteins LAP1 or Torsina Causes Abnormal Lipid Droplet Accumulation and Nonalcoholic Steatohepatitis in Chow Fed MiceAuthors: Howard Worman, Ji-Yeon Shin, Henry Ginsberg, William Dauer, Antonio Hernendez-Ono, Tatyana Fedotova, Michael Lee, Cecilia OstlundYou must log in to access content.
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1300: Icosabutate, a Novel Structurally Engineered Fatty-Acid, Exhibits Potent Anti-Inflammatory and Anti-Fibrotic Effects in a Dietary Mouse Model Resembling Progressive Human Non-Alcoholic SteatohepatitisAuthors: David Fraser, Detlef Schuppan, Xiaoyu Wang, Tore SkjaeretYou must log in to access content.
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