The Liver Meeting 2024 - Debrief Sessions - Spanish-Liver Transplantation Debrief Session

Video Transcription

Video Summary

Dr. Jacqueline O'Leary discussed key themes from the recent AASLD conference concerning liver transplantation. With 279 abstracts submitted, she highlighted significant trends and studies. Predictive scores and outcomes were the most common topics, followed by disparities, alcohol-related issues, and biomarkers. Notably, machine perfusion, though promising, remains underutilized due to cost. The importance of immunosuppression personalization was emphasized, with promising results in ongoing trials for CAR T-reg cell therapy aimed at reducing post-transplant immunosuppression. Studies on survival outcomes showed no significant advantage between cold storage and machine-perfused grafts, although advancements in predictive scoring, such as MELD 3.0, marked progress in equity, especially benefiting female patients. Metabolic impacts, particularly through GLP-1 agonists, were examined, showing metabolic health improvements post-liver transplant. Disparities in liver transplant access and outcomes remain a critical concern, necessitating ongoing efforts toward more effective intervention and policies.

Keywords

liver transplantation

predictive scores

immunosuppression personalization

machine perfusion

disparities

biomarkers