The Liver Meeting 2024 - Debrief Sessions - Portuguese-Pediatric Debrief Session

Video Transcription

Video Summary

In the debrief meeting, Dr. Rohit Kohli from USC discussed key findings in pediatric liver disease. The Pediatric Acute Liver Failure Immune Response Network study highlighted the role of CD8-positive cells in immunity, a finding that may affect treatment strategies. Researchers at Texas Children's introduced an ultrasound technique to detect biliary atresia in infants with high sensitivity and specificity, suggesting it could reduce the need for surgical interventions. A long-term study of intrapathic cholestasis revealed varying fibrosis stages and cancer risks, emphasizing the need for further understanding and precise treatments. SickKids' research indicated that IgG levels in children could predict autoimmune hepatitis disease activity better than ALT. Finally, the importance of addressing pruritus in PFIC for growth outcomes was discussed, alongside a presentation on metabolic dysfunction-associated liver disease, highlighting multidisciplinary care and potential research directions such as natural history, imaging, and treatment options.

Keywords

pediatric liver disease

CD8-positive cells

biliary atresia

autoimmune hepatitis

intrapathic cholestasis

metabolic dysfunction-associated liver disease