The Liver Meeting 2024 - Debrief Sessions - Portuguese-Basic Science Debrief Session

Video Transcription

Video Summary

The Liver Meeting Debrief Session Two, moderated by Dr. Carla Brady and Dr. Debbie Shawcross, featured six notable studies covering various aspects of liver disease research. Yaron Rotman from NIDDK highlighted key research on basic science. One study, by Dr. Ma from Yale, explored portal hypertension and its effects on liver remodeling, identifying VCAM-1 as a potential therapeutic target. Another study, from Dr. Kato at Osaka, investigated fibrosis due to hepatic congestion and suggested anti-integrins as a treatment. Cancer research was also covered, with Dr. Lemaitre from Stanford examining immune evasion in hepatocellular carcinoma. Additionally, Dr. Zhang from Seoul demonstrated how DPP-4 inhibition might enhance immune response to cancer. Studies on alcohol-related liver disease revealed potential therapies involving BTK inhibitors and the role of lipids in disease progression. Lastly, research on acetaminophen toxicity and biliary senescence provided insights into cell signaling and potential therapeutic interventions, aiming to improve understanding and treatment of liver diseases.

Keywords

liver disease

portal hypertension

fibrosis

hepatocellular carcinoma

alcohol-related liver disease

acetaminophen toxicity