The Liver Meeting 2024 - Debrief Sessions - Portuguese-Basic Science Debrief Session

Video Summary

The Liver Meeting Debrief Session Two featured several presentations on liver disease research moderated by Dr. Carla Brady and Dr. Debbie Shawcross. Dr. Yaron Rotman from NIDDK highlighted key basic science studies. A study by Dr. Ma at Yale explored portal hypertension and its impact on liver remodeling, identifying VCAM1 as a potential therapeutic target. Dr. Kato from Osaka examined hepatic congestion and fibrosis, showing potential in using anti-integrin treatments. Research on cancer and liver disease revealed pathways that might help prevent tumor recurrence and improve therapies. Dr. Nagesh highlighted the potential of targeting BTK in alcohol-associated liver disease, while other studies investigated the effects of lipid alterations and S100A11 in MASH-related stress. Additionally, the role of beta and gamma-catenin in bile duct integrity, host factors in viral hepatitis, and liver lymphatics during regeneration were discussed. Finally, cutting-edge research involving humanized mice models aimed to improve the understanding of human liver diseases through more accurate animal models.

Keywords

liver disease research

portal hypertension

anti-integrin treatments

alcohol-associated liver disease

viral hepatitis

humanized mice models