The Liver Meeting 2023-Liver Cell Biology SIG

Video Transcription

Video Summary

The video session focused on spatial cellular interactions in liver health and disease, with speakers discussing liver fibrosis, metabolic zonation, B-cell interactions, and T-cell and dendritic cell interactions. Key points included the role of hepatic stellate cells and extracellular vesicles in liver fibrosis, Wnt signaling in metabolic zonation, B-cell activation in liver disease progression, and increased T-cells in non-viral liver diseases. The session highlighted various cellular interactions and pathways contributing to liver health and disease progression, such as autoimmune responses, clonal expansion of T-cells, plasma cell involvement, and the importance of Wnt signaling. Discussions also touched on the impact of Wnt signaling disruption on liver regeneration and the break of self-tolerance in metabolic-associated liver disease. Overall, the session shed light on the complexities of cellular interactions in liver diseases and emphasized the significance of spatial analysis in understanding liver cancer and disease progression. Audience questions also delved into topics such as the sources of Wnt signaling, the drivers of self-tolerance break in liver disease, and the role of different cells in liver regeneration.

Keywords

liver health

liver disease

spatial cellular interactions

liver fibrosis

metabolic zonation

B-cell interactions

T-cell interactions

dendritic cell interactions

hepatic stellate cells

extracellular vesicles

Wnt signaling

autoimmune responses