The Liver Meeting 2023-3065 - Cirrhosis As a Multisystem Disorder

Video Transcription

Video Summary

In this lecture, the speakers discussed acute kidney injury (AKI) in cirrhosis, emphasizing the importance of defining the condition based on serum creatinine levels and urine output within specific time frames. They highlighted that AKI affects about 50% of patients with cirrhosis and can lead to increased morbidity and mortality. The speakers also discussed how factors like volume depletion, acute tubular injury, and hepatorenal syndrome contribute to AKI in these patients. Biomarkers like urine NGAL were mentioned as potential tools for diagnosing AKI in cirrhosis. Additionally, the speakers reviewed prevention strategies, diagnostic evaluations, and personalized management approaches that consider the fluid status, liver health, and underlying AKI phenotype. They highlighted the importance of therapeutic interventions like large-volume paracentesis, balanced fluid administration, and vasopressor therapy for hepatorenal syndrome AKI. Finally, they stressed the significance of close follow-up after hospital discharge, with early involvement of primary care providers, hepatologists, nephrologists, and potentially palliative care teams for comprehensive patient care.

Keywords

acute kidney injury

cirrhosis

serum creatinine levels

urine output

morbidity

mortality

volume depletion

hepatorenal syndrome

biomarkers

therapeutic interventions