The Liver Meeting 2023-3064 Cirrhosis As a Multisystem Disorder

Video Transcription

Video Summary

In today's session, Dr. Renu Dhanasekaran from Stanford University discussed cirrhosis as a pre-malignant condition, mechanisms, and clinical applications. She highlighted the multi-step cancer progression in HCC and the genetic and epigenetic changes that accumulate during cancer initiation in the cirrhotic liver. Dr. Dhanasekaran also discussed the role of the gut-liver axis and how dysbiosis can contribute to chronic inflammation and oxidative stress, leading to cancer initiation. She emphasized the importance of early detection and potential interventions to prevent cancer in patients with cirrhosis. In a lively debate, the speakers discussed the use of antibiotic prophylaxis in patients with ascites, with differing opinions on the indications and implications of primary prophylaxis. Dr. O'Leary advocated for individualized decision-making based on patient characteristics, while Dr. Wong emphasized the need for more evidence to support the routine use of prophylactic antibiotics. Overall, the session provided valuable insights into the complexities of managing cirrhosis and liver cancer, highlighting the importance of personalized approaches and ongoing research to improve patient outcomes.

Keywords

cirrhosis

pre-malignant condition

cancer progression

HCC

genetic changes

epigenetic changes

gut-liver axis

dysbiosis

early detection

antibiotic prophylaxis