The Liver Meeting 2023-2023 TLM Debrief Session (Basic Science Debrief)

Video Transcription

Video Summary

The debrief session from the 2023 liver meeting in Boston covered various topics in basic science, viral hepatitis, muscle hypertension, and cholestatic liver diseases. The basic science session focused on gut-liver crosstalk, fibrosis, and IPSC models. Speakers highlighted new findings on gut epithelium role in liver disease, HIF-1-alpha's impact on gut barrier function, and osteopontin's protective effects against liver disease. The fibrosis section discussed glycolysis's role in fibrosis progression, ERAD's impact on collagen secretion, and macrophage populations in fibrosis regression. IPSC models were introduced for studying hepatitis B infection, PFIC-1 disease, and NAFLD. Tools like humanized mouse livers, genetically engineered mouse models of HCC, and 3D bioprinting for NASH were presented. Lastly, the session touched on the underappreciated role of environmental toxins and the importance of lymphatics in liver fibrosis and cirrhosis.

Asset Caption

Rebecca Wells, MD: Basic Science Debrief

Keywords

liver meeting

basic science

viral hepatitis

muscle hypertension

cholestatic liver diseases

fibrosis progression