The Liver Meeting 2022-Leon Schiff State-of-the-Art Lecture

Video Transcription

Video Summary

Dr. Jacqueline Marr, a professor of medicine and gastroenterology at the University of California, San Francisco, gave a lecture on the evolution of disease modeling in non-alcoholic fatty liver disease (NAFLD). She discussed various mouse models and their limitations in simulating the human disease. One of the earliest models discussed was the obese mouse, which has a defect in the leptin gene and develops obesity and fatty liver. However, these mice do not exhibit the metabolic features of human NAFLD. Other mouse models were also explored, including those with spontaneous or engineered mutations that predispose them to hepatic steatosis. Another model discussed was the methionine choline-deficient (MCD) diet, which induces fatty liver but lacks the metabolic features of human NAFLD. Dr. Marr also discussed the role of adipose tissue-liver interactions, the microbiome, and the impact of diet on disease progression. She highlighted the need for models that can better mimic human NAFLD and discussed the use of induced pluripotent stem cells (iPSCs) as a promising approach. Dr. Marr concluded that a combination of mouse models and human models, along with multiomics data, will help advance our understanding of NAFLD.

Asset Caption

Presented by Dr. Jacquelyn J. Maher, Department of Medicine, University of California San Francisco

The objective of this program is to provide learners with a longitudinal perspective of disease modeling in NAFLD over the last 20 years. Emphasis will be placed on the shift from animal human models, the latter taking advantage of new research technologies. The advantages and limitations of each will be discussed.

Keywords

NAFLD

mouse models

metabolic features

hepatic steatosis

microbiome

diet

iPSCs