The Liver Meeting 2021-Using Single Cell Genomics Approaches to Decode Human Liver Disease

Using Single Cell Genomics Approaches to Decode Human Liver Disease

Video Transcription

Video Summary

Professor Neil Henderson from the University of Edinburgh presented a lecture on using single-cell genomics approaches to decode human liver disease. His work focused on understanding the cellular and molecular mechanisms driving liver fibrosis using technologies like single-cell RNA sequencing and spatial transcriptomics. By analyzing healthy and cirrhotic liver tissue, he identified distinct cell populations like scar-associated macrophages and endothelial cells enriched in disease states. Through ligand-receptor interaction analysis and validation experiments, he unveiled the interactions driving liver fibrosis. Henderson highlighted the rapid advancements in single-cell technologies and their potential for precision medicine in liver disease treatment. Collaborations with researchers and open access to data sets are key to advancing research in this field.

Keywords

single-cell genomics

human liver disease

liver fibrosis

single-cell RNA sequencing

spatial transcriptomics

precision medicine