The Liver Meeting 2021-Overlap Syndromes: A Special Interest Group Update

Video Transcription

Video Summary

The symposium focused on discussing the pathogenesis, diagnosis, and management of autoimmune liver diseases, including PBC and autoimmune hepatitis, highlighting the challenges in diagnosing and managing these conditions. Presenters emphasized the importance of expert biopsy interpretation and the need for further research, especially in overlap syndromes. Additionally, the session covered topics such as histopathology, overlap with primary sclerosing cholangitis, and autoimmune injury features in liver biopsies. The video transcript highlighted the significance of understanding the cellular makeup of the liver, using single cell transcriptomic technology to create comprehensive cellular maps for studying liver diseases like primary sclerosing cholangitis. The study involved profiling cell populations in healthy and diseased livers, addressing challenges like tissue dissociation and patchy disease distribution. Through various technologies, different cell populations were identified, and factors like zonation, immune cell infiltration, and biliary proliferation in PSC were investigated. The goal is to define and target autoimmune liver diseases by understanding the cellular biology of the liver through a multi-dimensional approach. This research underscores the complexity of the liver and the need for in-depth studies to comprehend liver health and disease.

Keywords

autoimmune liver diseases

PBC

autoimmune hepatitis

diagnosis challenges

management challenges

biopsy interpretation

overlap syndromes

histopathology

primary sclerosing cholangitis

autoimmune injury features

single cell transcriptomic technology

cellular maps