The Liver Meeting 2021-Inflammation and Cell Death in ALD

Video Transcription

Video Summary

Dr. Laura Nagy, a Professor at the Cleveland Clinic, delivered the Zimmerman Hepatotoxicity State-of-the-Art Lecture on Inflammation and Cell Death in Alcoholic Liver Disease. Dr. Nagy discussed the impact of alcohol on the liver, including the progression from steatosis to cirrhosis, hepatocellular carcinoma, and alcohol-associated hepatitis characterized by inflammation and cell death. Through her research program focusing on signal transduction and innate immunity in liver diseases, Dr. Nagy emphasized understanding mechanistic insights to translate basic science to clinical application. She presented findings on monocyte function alterations in alcoholic hepatitis and highlighted the role of C-type lectin receptors in immune surveillance. Additionally, Dr. Nagy explored the involvement of death receptor signaling pathways, specifically necroptosis, in ethanol-induced liver injury. By investigating the differential roles of RIT3 and MLKL in alcoholic liver disease and NAFLD/NASH models, potential biomarkers for distinguishing these conditions were identified. Dr. Nagy's work offers valuable insights into the mechanisms underlying liver diseases and potential diagnostic markers.

Keywords

Dr. Laura Nagy

Zimmerman Hepatotoxicity State-of-the-Art Lecture

Alcoholic Liver Disease

Inflammation

Cell Death

Monocyte Function Alterations

C-type Lectin Receptors