The Liver Meeting 2021-Gut-Liver Interaction on Liver Disease

Video Transcription

Video Summary

The Liver Cell Biology Special Interest Group session focused on the gut-liver interaction in liver disease, organized by a steering committee of experts. The program included talks on FXR-mediated intestine-liver communication, bile acid synthesis differences between humans and rodents, and the role of FGF15 and FGF19 in regulating liver functions. The speakers highlighted the importance of FXR in maintaining bile acid homeostasis and its implications in treating liver diseases and metabolic syndromes. The discussions also touched upon intestinal regulation of hepatic cholesterol metabolism and the impact of alcohol-associated liver disease on the gut-liver axis. Additionally, studies on hepatic adaptation to changes in bile acid environments revealed insights into YAP1's role in liver development and bile duct formation. The research showcased the complex interplay between bile acids, signaling pathways, and liver adaptation mechanisms in response to environmental changes.

Keywords

Liver Cell Biology

Gut-Liver Interaction

Liver Disease

FXR-mediated Communication

Bile Acid Synthesis

FGF15 and FGF19

Bile Acid Homeostasis

Metabolic Syndromes

Cholesterol Metabolism

Alcohol-associated Liver Disease

YAP1 and Bile Duct Formation