The Liver Meeting 2021-Cross-Platform Analyses of Human Biopsies Provide Insights into the Liver-based Immune Responses

Cross-Platform Analyses of Human Biopsies Provide Insights into the Liver-based Immune Responses

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Video Summary

Dr. Anthony Demetrius, a distinguished pathologist from the University of Pittsburgh Medical Center, focuses on liver and transplantation pathology. His research delves into the immune microenvironment in human livers and allografts. Dr. Demetrius emphasizes the importance of next-generation pathology, showcasing advancements in digital imaging, multiplexing, and automated analysis. By utilizing high-resolution digital imaging, his laboratory gains insights into immune responses in liver biopsies. He highlights the significance of spatial context and the evolving role of antibodies and T-cells in liver injuries. Dr. Demetrius shares findings on antibody-mediated rejection, immune synapse formation, and the impact of immune microenvironment on T-cell maturation. His innovative approach integrates data from various platforms to understand tissue biology comprehensively, aiding in research and patient care.

Keywords

Dr. Anthony Demetrius

University of Pittsburgh Medical Center

liver pathology

transplantation pathology

immune microenvironment

digital imaging