The Liver Meeting 2021-Blood Coagulation in Drug-Induced Liver Injury-Basic Mechanisms and Clinical Applications

Blood Coagulation in Drug-Induced Liver Injury-Basic Mechanisms and Clinical Applications

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Video Summary

In this symposium, the role of various proteins such as von Willebrand factor, chitinase 3-like protein, and CD44 in drug-induced liver injury, specifically from anticoagulation and acetaminophen overdose, was discussed. Von Willebrand factor was found to play a role in promoting hepatic platelet recruitment and contributing to liver injury in acetaminophen overdose models. This was supported by clinical evidence showing elevated levels of von Willebrand factor in patients with a siminofin overdose-induced liver failure. Chitinase 3-like protein was also identified as a contributing factor in siminofin-induced liver injury, primarily by promoting hepatic platelet accumulation. The mechanism was found to involve CD44 as the receptor mediating chitinase 3-like protein function. Additionally, the role of podoplanin, a binding partner for chitinase 3-like protein, and its impact on platelet adhesion and liver injury was explored. Monoclonal antibodies targeting chitinase 3-like protein were shown to effectively reduce platelet accumulation and liver injury in siminofin-induced liver injury models. In conclusion, these findings shed light on the intricate mechanisms underlying drug-induced liver injury and provide potential targets for therapeutic interventions.

Keywords

proteins

von Willebrand factor

chitinase 3-like protein

CD44

drug-induced liver injury

anticoagulation

acetaminophen overdose

hepatic platelet recruitment

siminofin overdose

liver failure

podoplanin