The Liver Meeting 2021-Basic Science Debrief

Video Transcription

Video Summary

Heather Francis from Indiana University School of Medicine presented highlights from various abstracts focusing on liver fibrosis, brain dysfunction, cholestatic liver injury, myeloid cells, alcohol-associated liver disease, gut microbiota, and liver regeneration. Key findings included glycolysis in hepatic stellate cells promoting liver fibrosis, sphingolipid metabolism in brain dysfunction, interferon-gamma's role in cholestatic liver injury, and NK1 receptor in alcohol liver disease. Additionally, studies explored immune cell recruitment in liver fibrosis and the therapeutic potential of VEGF-A for liver regeneration. Gut microbial factors activation in intrahepatic B cells leading to non-alcoholic steatohepatitis was also discussed. The need for future research on gut-liver interactions and liver fibrosis was emphasized.

Keywords

liver fibrosis

brain dysfunction

cholestatic liver injury

alcohol-associated liver disease

gut microbiota

liver regeneration