The Liver Meeting 2020-Liver Cell Biology in Hepatic Diseases SIG Cellular Senescence in Liver Disease and Aging

Liver Cell Biology in Hepatic Diseases SIG Cellular Senescence in Liver Disease and Aging

Video Transcription

Video Summary

The video transcript discusses the Liver Cell Biology in Hepatic Disease SIG Symposium on Cellular Senescence in Liver Disease and Aging. Cellular senescence is highlighted as a cell cycle arrest program related to pro-inflammatory cytokine secretion and mitochondrial dysfunction. The symposium delves into how experts are translating basic science discoveries into therapeutic strategies for liver diseases like HCC fibrosis and cholangiopathies. Various speakers present on topics such as the basic concepts of cellular senescence, the impact of aging on liver cells and disease, senescence in biliary diseases, telomere length, aging, liver tumors, and the role of senescence in liver fibrosis. The lectures also cover the potential therapeutic strategies targeting senescent cell anti-apoptotic pathways and senescence-associated secretory phenotype to counteract the negative effects of senescent cells in aging and age-related diseases. The speakers discuss the interactions between biliary senescence, melatonin signaling, and the regulation of angiogenic signaling, with the aim to reduce biliary damage and liver fibrosis. Studies in preclinical models demonstrate the effects of targeting key factors like P16, MT1, and MT2, as well as exploring the potential mechanisms linking P16, melatonin, 200B, and angiogenesis. The presentation ends with gratitude to all the collaborators and support for the symposium. The goal is to contribute to the understanding of how aging impacts liver disease and cellular senescence, paving the way for potential therapeutic interventions.

Keywords

Liver Cell Biology

Hepatic Disease

SIG Symposium

Cellular Senescence

Pro-inflammatory Cytokine Secretion

Mitochondrial Dysfunction

Liver Diseases

HCC Fibrosis

Cholangiopathies