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Catalog
The Liver Meeting 2020
Hepatotoxicity SIG The Basic Mechanisms of Hepatot ...
Hepatotoxicity SIG The Basic Mechanisms of Hepatotoxicity and Their Clinical Implications
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Video Transcription
Video Summary
The virtual SIG symposium at the ASLD entitled "The Basic Mechanisms of Hepatotoxicity and Their Clinical Implications" featured presentations from leading investigators in the field focusing on molecular mechanisms involved in hepatocellular injury and immune system activation. Dr. Neal Kaplowitz discussed hepatocyte stress response, mitochondrial dysfunction, and oxidative stress. Dr. Bruno Stigler presented on liver injury alteration and bile acid homeostasis. Dr. Jack Utrecht talked about adaptive immune injury and neoantigen formation, and Dr. Andy Stults reviewed epigenetics and genetic pathways to hepatotoxicity. They highlighted the role of different pathways and genes, such as ADME genes, HLA associations, and PTPN22 variants in drug-induced liver injury. The symposium also touched on the impact of epigenetics on hepatotoxicity and the potential for future biomarkers and genetic screening to inform individuals at risk for DILI. The importance of environmental factors and epigenetic changes in liver injury was also discussed. Attendees were encouraged to participate in the monthly hepatotoxicity seminars to continue learning and exchanging information in the field. The chairman of the Hepatotoxicity Special Interest Group, Adrian Rubin, expressed gratitude to the organizers, faculty, and attendees, urging everyone to stay safe during the ongoing pandemic.
Keywords
Hepatotoxicity
ASLD
SIG symposium
Molecular mechanisms
Hepatocellular injury
Immune system activation
Mitochondrial dysfunction
Oxidative stress
Bile acid homeostasis
Adaptive immune injury
Epigenetics
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