The Liver Meeting 2020-Hepatotoxicity SIG The Basic Mechanisms of Hepatotoxicity and Their Clinical Implications

Hepatotoxicity SIG The Basic Mechanisms of Hepatotoxicity and Their Clinical Implications

Video Transcription

Video Summary

The virtual SIG symposium at the ASLD entitled "The Basic Mechanisms of Hepatotoxicity and Their Clinical Implications" featured presentations from leading investigators in the field focusing on molecular mechanisms involved in hepatocellular injury and immune system activation. Dr. Neal Kaplowitz discussed hepatocyte stress response, mitochondrial dysfunction, and oxidative stress. Dr. Bruno Stigler presented on liver injury alteration and bile acid homeostasis. Dr. Jack Utrecht talked about adaptive immune injury and neoantigen formation, and Dr. Andy Stults reviewed epigenetics and genetic pathways to hepatotoxicity. They highlighted the role of different pathways and genes, such as ADME genes, HLA associations, and PTPN22 variants in drug-induced liver injury. The symposium also touched on the impact of epigenetics on hepatotoxicity and the potential for future biomarkers and genetic screening to inform individuals at risk for DILI. The importance of environmental factors and epigenetic changes in liver injury was also discussed. Attendees were encouraged to participate in the monthly hepatotoxicity seminars to continue learning and exchanging information in the field. The chairman of the Hepatotoxicity Special Interest Group, Adrian Rubin, expressed gratitude to the organizers, faculty, and attendees, urging everyone to stay safe during the ongoing pandemic.

Keywords

Hepatotoxicity

ASLD

SIG symposium

Molecular mechanisms

Hepatocellular injury

Immune system activation

Mitochondrial dysfunction

Oxidative stress

Bile acid homeostasis

Adaptive immune injury

Epigenetics