The Liver Meeting 2020-Hans Popper Basic Science State-of-the-Art Lecture Modeling Development and Cancer Using Liver and Biliary Organoids

Hans Popper Basic Science State-of-the-Art Lecture Modeling Development and Cancer Using Liver and Biliary Organoids

Video Transcription

Video Summary

The speaker expressed gratitude for the opportunity to give the prestigious Hans Popper lecture. The focus of the talk was on modeling development and cancer using liver and biliary organoids. They discussed the importance of understanding how tissues maintain and repair themselves in the context of disease. The lab uses liver as a model organ due to its high repair capacity. By studying hepatoblast-derived organoids, they explored liver development and biopotency. They also investigated cholangiocyte organoids to understand duct-mediated liver regeneration mechanisms. Human liver cancer organoids were used to model and investigate liver cancer for personalized medicine, showing promising results in drug sensitivity testing. Through various projects and collaborations, the research team demonstrated how these organoid models can mimic the characteristics of human liver tissues and cancers, providing valuable insights for further research and potential clinical applications.

Keywords

Hans Popper lecture

development modeling

cancer organoids

liver repair

biopotency

liver regeneration

personalized medicine