The Liver Meeting 2020-AASLD/NASPGHAN Pediatric Symposium Medical and Ethical Dilemmas of Patient and Organ Selection for Liver Transplantation

AASLD/NASPGHAN Pediatric Symposium Medical and Ethical Dilemmas of Patient and Organ Selection for Liver Transplantation

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Video Summary

The 2020 ASLD NASPGAM Pediatric Symposium centered on medical and ethical challenges related to liver transplantation, aiming to discuss controversies and expand the organ donor pool. Discussions included ethical considerations in deceased and living donor liver transplants, strategies for expanding the donor pool such as DCD utilization and split liver transplants, and the importance of risk stratification for high-risk liver tumors. Mitochondrial hepatopathies, a group of disorders stemming from mitochondrial dysfunction, were also explored. Diagnosis involves genetic testing, and while liver transplant is a potential treatment, its role remains controversial due to concerns about donor shortages and varied post-transplant outcomes based on specific genetic disorders and neurological involvement. A personalized approach focusing on genotype-phenotype correlations is essential in determining the suitability and benefits of liver transplant in mitochondrial hepatopathies. Additional research and an international registry could aid in improving decision-making and outcomes for these complex disorders. Overall, the symposium highlighted the evolving landscape of pediatric liver transplantation, emphasizing the importance of ethical considerations, improving patient care, and maximizing donor utilization.

Keywords

ASLD NASPGAM Pediatric Symposium

medical challenges

ethical challenges

liver transplantation

organ donor pool

DCD utilization

split liver transplants

risk stratification

high-risk liver tumors

mitochondrial hepatopathies

genetic testing

personalized approach