The Liver Meeting 2020-AASLD/EASL Joint Symposium Steatohepatitis in Fatty Liver Disease: In Europe and U.S.

AASLD/EASL Joint Symposium Steatohepatitis in Fatty Liver Disease: In Europe and U.S.

Video Transcription

Video Summary

In summary, the growing public health burden of NAFLD in the United States and Europe is projected to have significant impacts on liver-related outcomes if left unaddressed. Early life interventions, including prenatal and postnatal exposures, such as maternal obesity, gestational diabetes, and breastfeeding, have been shown to impact the risk of developing NAFLD in children and adolescents. These interventions can influence metabolic programming and epigenetic mechanisms that contribute to increased susceptibility to chronic diseases later in life. Targeted interventions focused on maintaining a healthy weight prior to conception, promoting a non-Western diet, breastfeeding, and encouraging regular exercise in childhood can potentially mitigate the escalating NAFLD epidemic and its associated morbidities. As we continue to unravel the complexities of developmental origins of health and disease, more research is needed to provide tailored recommendations and optimize public health strategies to combat the NAFLD epidemic. Thank you for your attention.

Keywords

NAFLD

public health burden

United States

Europe

liver-related outcomes

early life interventions

prenatal

postnatal exposures

maternal obesity

gestational diabetes

breastfeeding

metabolic programming