The Liver Meeting 2019-Therapeutic Benefits of Statin in Chronic Liver Diseases

Therapeutic Benefits of Statin in Chronic Liver Diseases

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Video Summary

The speaker discusses the therapeutic benefits of statins in chronic liver diseases, focusing on their pleiotropic effects beyond just lowering cholesterol levels. They explain the mechanisms by which statins work in the liver, notably through anti-fibrotic properties, pro-vascular phenotypes, and inhibition of inflammation and cell death. Evidence from studies in animal models and some clinical trials suggest that statins may improve liver function, reduce portal pressure, and even increase survival rates in patients with cirrhosis. Potential benefits include prevention of liver diseases like steatosis, fibrosis, and even hepatocellular carcinoma. However, precautions are advised, especially in patients with severe liver disease, as there is a risk of liver and muscle toxicity. More research is needed to establish statins as a standard treatment for chronic liver diseases.

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Presenter: Jaime Bosch

Keywords

therapeutic benefits

statins

chronic liver diseases

pleiotropic effects

anti-fibrotic properties

liver function