Good evening, gentlemen and friends. I would like to thank the organizers for inviting me to present a ten-year journalism school named Precision Medicine in Clinical Practice. My job today is to give you an example of the spectrum of Precision Medicine. Let me start by deciding that I have nothing to decide. Albert Einstein had to say that our imagination is our problem in our life experiences. Therefore, I thank you to consider whether the problem of the experience of genetic experience is lower. Time experiences are better recorded and used. Movement is common. The movement usage is just that and less toxic. And the refugee experience becomes safer and more immediate for our children. I would also like before I start my discussion to do some business about what the refugee experience is as recorded by the EKS a few years later. The refugee experience is recorded as a recording of the experience at a deeper level to better record the outcome of the experience as well as to develop more related treatments. This is in accordance with the refugee experience which mentions refugee treatment among the specific characteristics of the refugee experience. In my presentation today I would like to convince you that genetics have a role in treatment and I will present with some examples that are evident in practice to reiterate how these areas are already affecting Out of 4 million genetics every year is about 3% of people 120,000 people every year will be born with genetic therapy or with a major problem that will remain forever. We now know that about 10% of siblings and about 30% of children settle on a daily basis due to a genetically related condition. Also, we know that motivation is probably installed in about 20% of people that create this situation. And as George said before, I think it's possible that we're involved in using thought technologies and specifically the next genetic technology because this unique tool can allow us to participate in clinical work. And we have done it, we do it because the next genetic technology is safe, safe and secure. And when something becomes safe, secure, and secure, then it becomes part of the job, no matter what. I also want to mention the huge program we have done over the last 20 years. This is a scene from JAN. When the latest genetic technology started, they made money to specify two people in about 100 million dollars for the born. Because there was an important program in the way we could continue this test, we can do this test today for reasonable reasons close to $1,500. And in this scene I want to mention how we can do. This is a scene showing a portine nativity where you can see three nativity in the outer and outer as well as in the outer regions. Using genetic engineering testing, we can now classify many offspring that we want to build for a paraeducator. which may have behavior with family history. This is what we call a genopanel test. We can do something more external and more external, so to speak entire external technology, where we try to understand the system and technology of the approximately 20,000 genes that the human being has at enough price for practice. And finally, we are in the space now that we can do generational system where we can systematize the whole 3 billion system human's. All of this became a possibility because of advances in DNA sequencing technology. And so, let's go to this opportunity and think otherwise, to think sensitively. In my talk, as I said, I will give you the spectrum of practice and how it is based on the application of our developments. This list is very long and growing. I will talk about all of the following specifically for children who are on the diagnostic journey. I will communicate the preparation of outgoing cardiac and outgoing concrete. I will not talk about prenatal preparation and free DNA. But this is the same technology for most of the day. There is a lot of work going on. in many areas today to try to use general panelists to understand several activities in many tasks There is a larger area to understand genomes for opposite healthy and there is value, I will and we all know that the microbe is likely to remain for a long time, because it affects every activity. And ultimately pharmacogenomic probability is important to everything we do in practice. We have to show you some traditions about how this produces. But let's start by using the tradition of the non-diagnostic university. What is a non-diagnostic university? What else is what we call diagnostic odyssey. This is a situation where there is a situation where there is One was from China and the other was from Europe through international connections and all this work that happens on the internet today where we associate kingdoms with discoveries of this nature and then we did activities some of what we see here where we took population of population and we generated that this rin-1 prime is lower in population 1 and 3 the population population was achieved of these population capture episodes dealing with dominions and really the embolism at 40 ranks worked more the first and the expression of these populations by confronting the sovereignties We have additional creators outside of these confrontations that I will not go into here But I would like to concentrate and say that using the following aggregation we have created the discovery of a new generic that replicates the clinical phenotype and now we know that the gradations in general of Riduan create a mode of self-compassionate reciprocity as well as other phenotypic subtleties which I will not proceed today But to proceed that outgoing concentration we could not create this discovery to understand what creates this spirituality This is important not only for the child but also for those families who want to know if they should try to have more children in the future what should they do It's not about treatment but that would be our goal And so, dealing with this this is not the end we started creating almost five years or more In 2012 we made about 12 children, in 2013 we made 50 children Now we specifically see 500-600 children every year and almost all of them go on to have an outgoing concrete We found, like others, that in about 30% of the outgoing concrete they give the answers In about 10% from them we can deal with the treatment of these children This shows the power of the outgoing specific vortex in reactions I am now in the outgoing specific vortex We see them all the time in practice They are very common There are the fati pound, the cholestatic pound and all that between And I want to go ahead a risk to think about children and equipment I'm in Minnesota for the last 25 years of my life and I think I am satisfied to talk about the smile As you can see here these smiles play the same but at the same time they are different The same are our children This is the aim and goal of practice equipment If we play these smiles and we think they are different we can still communicate as I see here on the right side this is the goal of the practical equipment if you want The important thing I want to do is that for some of these producers it's the important thing I want to do This important important I will also talk about this nice text from France by Haki Mettol where it should be with the approach of the following specific to process players with idiosyncratic community These were people with less than 40 years of community 19 of them Also, as I talked about later About the following specific about 25-26% of them 5 out of 19 had specific joints that were not found clinically or in other ways that we use in practice 2 of them had mitacases of ABCD4 To be clear here there are players at times that I think, even in our practice as we speak now, may help with the following specific We're moving on to another area now, and I think I'll have a lot to do in my 20 minutes, but I want to outline and say that practical genomics it's something we want to build for our players because times change The player will see you now That's not what we want to do to our players, it's what they want to know about you and their kind or the next or the risk to the art community With that important, in 2014 we created a hands-on genomic clinic to take people who were otherwise healthy and test them for specific panels based on their sometimes created by family and sometimes created by an interest in knowing what their gender or lineage means to them We started in 2014 with the Illumina family of outdoor equipment and continued with the equipment and continued to follow it up with the panel equipment for cardiopulmonary bypass and cardiopulmonary bypass and more recently, in the last two years equipped for the newborn who examines at the moment about 600 newborns As we do this analysis in this hands-on genomic clinic we get people who want to meet We have a partnership with the master to build the kits and as you can see about 20-25% of the people out of the 1200 who were interested in coming and talking to us took some kind of test we used one of these panels or these platforms What we found important in our theory is that between 9%-20% have evaluative pathogens In the previous mode when I did it for exams this amount was about 35% This man may know something we don't and they come to test us This is something to think about and we do more tool to understand it better Four of them with evaluative pathologies have a private history but many of them, four did not This is one of the best traditions for a child with metastatic motor use As you can see here the child with metastatic use on the right probably a very limiting table for the spiritual attitudes, styles and treatments we have today and I believe that this will go ahead and we will have more opportunities to build this human soon in the near day. What should we do, we should invest more in the state of pathogenicity and all the other lapses which appear in the development of the movement, as well as finding ways to make these treatments easier, because diagnostically we are there, therapeutically we are not, but that is where we want to go. Finally, I would like to communicate this world of pharmacogenomics, the space that tells us how we all metabolize transitions. This is a large area of work, which has been created to make discoveries. What if everyone knows what actions and dosages are safe and practical. We know how to test people from experience, but we don't test them in the realm of genotypes. We also know that approximately 1.5 billion refugees in this space have activity development and advisors over time. This is a huge cost for what these people are dealing with through therapeutic treatments that would otherwise be there to treat them for a condition. A few years ago, we took about 1,000 Mayo Biobank participants and had to approach this way of testing. We were saying to test these people for five applications that are applicable for many different tests. As you can see here, we found that 99% of people had one of these different tests. 99% of those people had an app. Also, I want to encourage that when we do this way of examination, this was my activity, we think not only about the prospect, not only about the player, but about the families and that is important in many cases. Now, I've used the last 20 minutes to talk about geogenomics because I'm a DNA guy, but at the same time, I realize more and more that DNA is important, but other non-DNA, supra-DNA elements are also critical. We know epigenetics is important. We know that the variable and the microbiome are important. We know photography is important. We know exposure is important. The transcribed, you can see the story, where it goes. We must be able to work together in all these areas of inquiry to better understand creation, to better consider our personal selves. There are many opportunities for activity. The cost of treatment goals is huge. There is the black thing of the born that we do not know and we must consider and understand more to better consider our own. There are other opportunities. There is a huge reach to make games, but the assessment of these games, these great games, these great sciences, is not his job. We need to think about the medical room of these games we are talking about and the special participation in jobs. And we must consider the work of the future. We're behind that, I think. What I want to take away from this presentation today is to tell you the next thing. The medical room is here to stay and work has already affected our practice. The medical room is not designed with genomics in mind. We need to do more work, apply some science, to evaluate the medical room number in the service of games I would like to end my discussion with my books. This is where we were 20 years ago for genetic testing. This is where we are today. This is where I would like to go to see the full photo. Thank you for your attention.

Precision Medicine

Genetics

DNA Sequencing

Genetic Testing

Personalized Medicine

Pharmacogenomics