The Liver Meeting 2019-The Genetic Signatures of Tolerant and Non-tolerant Allografts

The Genetic Signatures of Tolerant and Non-tolerant Allografts

Video Transcription

Video Summary

The speaker discusses the complexities of genomics and genetics in relation to tolerance versus non-tolerance in transplant recipients. They focus on gene expression profiles that may predict successful outcomes in immunosuppression withdrawal. Different genetic markers and pathways are explored, indicating distinct responses in liver and kidney transplants. The discussion also includes the potential use of biomarkers in monitoring rejection and adjusting immunosuppression to prevent graft injury. The importance of understanding molecular profiles, such as microRNA and proteoforms, in identifying rejection early on is emphasized. In conclusion, the speaker highlights the evolving role of genomics in clinical practice for optimizing transplant management and potentially improving outcomes.

Asset Caption

Presenter: Josh Levitsky

Keywords

genomics

genetics

tolerance

transplant recipients

immunosuppression withdrawal