The Liver Meeting 2019-Resources to Help the Clinician Manage Hepatotoxicity: Focus on LIVERTOX

Resources to Help the Clinician Manage Hepatotoxicity: Focus on LIVERTOX

Video Transcription

Video Summary

The speaker highlighted Liver Talks, a website focused on drug-induced liver injury, which includes drugs that cause liver injury and those that don't. Liver Talks covers a variety of drugs, mostly from the US, including prescription and non-prescription drugs, herbal products, drugs of abuse, and metals, but excludes some categories like topical drugs and vaccines. The website features a formulaic structure for each chapter, including information on uses, mechanisms, common side effects, and likelihood scores of liver injury. The speaker discussed the evolution of Liver Talks, its migration to a new platform called Bookshelf with improved search capabilities, and the challenges of managing drug-induced liver injury, emphasizing the importance of monitoring and adapting treatment strategies. They also highlighted the decreasing trend in drugs causing liver injury due to improved identification and monitoring during drug development and post-approval phases. The role of genetic factors and adducts in predicting liver injury was also mentioned, along with the need for ongoing research and vigilance in managing drug-induced liver disease.

Asset Caption

Presenter: Jay H. Hoofnagle

Keywords

Liver Talks

drug-induced liver injury

prescription drugs

non-prescription drugs

mechanisms of liver injury

Bookshelf platform

genetic factors in liver injury