The Liver Meeting 2019-Long-Noncoding RNA Regulation of Liver Fibrosis

Long-Noncoding RNA Regulation of Liver Fibrosis

Video Transcription

Video Summary

The video discusses research on long non-coding RNAs and their role in liver fibrosis. The focus is on hepatic stellate cells, which transform into myofibroblasts responsible for chronic liver injury. Long non-coding RNAs do not encode proteins but play various cellular functions. By identifying specific long non-coding RNAs expressed in stellate cells, researchers aim to target them for therapeutic intervention. The study involves human and mouse cells, with a particular long non-coding RNA, TILAC, showing potential as a target to inhibit collagen production. Experiments in vitro and in vivo demonstrate the impact of depleting TILAC on collagen expression. The goal is to develop therapeutic approaches based on understanding these long non-coding RNAs in liver fibrosis.

Asset Caption

Presenter: Alan C. Mullen

Keywords

long non-coding RNAs

liver fibrosis

hepatic stellate cells

TILAC

therapeutic intervention