The Liver Meeting 2019-Liver Transplantation for ACLF: North American Experience

Video Transcription

Video Summary

The transcript covers liver transplantation for acute-on-chronic liver failure (ACLF) in North America. The definition of ACLF includes extrahepatic organ failures such as respiratory, renal, circulatory, and neurologic failure. The NAXLD-ACLF criteria require two or more organ failures for diagnosis. Patients with ACLF have varied outcomes based on the number of organ failures acquired. Liver transplantation outcomes are influenced by factors such as respiratory and brain failure. Patients listed for transplant tend to be younger, more likely to have spontaneous bacterial peritonitis, and higher MELD scores. ACLF patients show differences in mortality rates and MELD score progression post-transplant compared to those without ACLF. Steroid use for presumptive adrenal insufficiency and microbiota changes due to antibiotics are also discussed. Alcohol-related liver disease raises questions about transplant criteria and patient outcomes. The transcript explores treatment strategies, challenges, and considerations for ACLF patients in liver transplantation.

Asset Caption

Presenter: Jacqueline G. O'Leary

Keywords

liver transplantation

acute-on-chronic liver failure

ACLF

NAXLD-ACLF criteria

organ failures

transplant outcomes

treatment strategies