The Liver Meeting 2019-Inflammation and Beyond: Additional Pathophysiological Mechanisms of AKI

Inflammation and Beyond: Additional Pathophysiological Mechanisms of AKI

Video Transcription

Video Summary

The speaker discusses new developments in understanding hepatorenal syndrome with a focus on cirrhosis and ACLF. They highlight cirrhosis as a dynamic disease with potential reversibility. They explain how cirrhosis extends beyond the liver due to circulatory dysfunction and systemic inflammation. ACLF is a new entity within cirrhosis with high mortality driven by systemic inflammation. The talk contrasts classical and non-classical hepatorenal syndrome, emphasizing the role of systemic inflammation. They discuss how systemic inflammation worsens systemic circulatory dysfunction by increasing nitric oxide production and leads to renal damage. The mechanisms of renal damage in non-classical hepatorenal syndrome are explored, including immunopathology and immune metabolism disturbances. The talk concludes by emphasizing the spectrum of kidney injury in hepatorenal syndrome and the impact of systemic inflammation on kidney tissue damage.

Asset Caption

Presenter: Agustin Albillos

Keywords

hepatorenal syndrome

cirrhosis

ACLF

systemic inflammation

renal damage

immunopathology