The Liver Meeting 2019-HCV+ Donors in Heart/Lung Transplantation

Video Transcription

Video Summary

The speaker discussed heart and lung transplants using Hepatitis C infected donors for uninfected recipients. The concept of transmit and treat, along with prophylaxis to prevent infection, was highlighted. Challenges and opportunities in using infected donors were explored, comparing outcomes to pre- and post-DAA eras. Studies from Vanderbilt and Harvard showed successful outcomes with HCV treatment post-transplant. The transcript also detailed a study combining antiviral therapy with an entry inhibitor to prevent infection. Results showed prevention of infection in recipients with high donor viral loads. The approach was well-tolerated, cost-effective, and prevented virological failures. The benefits of prevention before hospital discharge and high patient acceptability were emphasized. The significance of addressing opioid epidemics to prevent donor tragedies was also underscored.

Asset Caption

Presenter: Jordan J. Feld

Keywords

transplant

Hepatitis C

prophylaxis

antiviral therapy

opioid epidemics