The Liver Meeting 2019-Gut Microbiome, Nuclear Hormone Receptors and Liver Fibrosis

Gut Microbiome, Nuclear Hormone Receptors and Liver Fibrosis

Video Transcription

Video Summary

Dr. John Chang from Northeastern Ohio Medical University discusses the intricate relationship between the gut microbiome, nuclear hormone receptors, and liver fibrosis. Bioacids, end products of cholesterol breakdown in the liver, play a crucial role in regulating metabolism, cholesterol levels, and obesity. Specific nuclear receptors such as FXR and TGR5 are activated by bioacids to maintain homeostasis and protect against diseases like non-alcoholic fatty liver disease. The gut microbiota heavily influences bioacid metabolism, shaping bioacid composition and pool size. Studies on FXR agonists and antagonists reveal their impact on gut microbiota and metabolism, showcasing the importance of bioacid signaling in metabolic regulation. Additionally, the FXR and TGR5 double knockout mice exhibit altered metabolic pathways and increased liver fibrosis, highlighting the critical role of bioacid signaling in metabolic homeostasis. Potential bioacid-based therapies are being explored for treating liver-related and metabolic disorders.

Asset Caption

Presenter: John Y.L. Chiang

Keywords

Dr. John Chang

Northeastern Ohio Medical University

gut microbiome

nuclear hormone receptors

liver fibrosis

bioacids

metabolic regulation