The Liver Meeting 2019-Drugs Targeted to Enhance Hepatic Regeneration

Video Transcription

Video Summary

In this video transcript, various strategies to enhance liver regeneration, particularly in the context of alcoholic hepatitis, are discussed. Impaired liver regeneration due to chronic liver injury, fibrosis, steatosis, and corticosteroid use is highlighted. The potential of regenerative therapies, including bioengineered scaffolds, reprogramming of cells, extracellular vesicles, and cell therapies, is explored. Specific focus is given to drug therapies such as GCSF and interleukin-22, which show promise in improving outcomes in patients with severe alcoholic hepatitis. The use of engineered bacteria producing IL-22 as a potential treatment for alcoholic liver disease is also mentioned. Clinical trials involving uric acid and the combination of anakinra, pentoxifilin, and zinc are discussed, although definitive recommendations for current practice remain limited to steroids for severe cases and supportive care.

Asset Caption

Presenter: Vijay Shah

Keywords

liver regeneration

alcoholic hepatitis

chronic liver injury

regenerative therapies

drug therapies

clinical trials