The Liver Meeting 2019-Dose, Duration and Drug Characteristics as Risk Factors for Liver Injury

Dose, Duration and Drug Characteristics as Risk Factors for Liver Injury

Video Transcription

Video Summary

Dr. Craig Lambert, an associate professor of medicine at Indiana University, presented a talk on drug-induced liver injury (DILI), focusing on factors like dose, drug characteristics, and duration. He discussed how DILI is a challenging clinical issue, often mimicking other liver conditions, and emphasized the importance of identifying risky drugs for patient safety. Lambert highlighted the impact of factors like dose, lipophilicity, solubility, and drug-drug interactions in DILI risk. He shared findings from studies on the relationship between drug characteristics and DILI, noting that drugs with daily doses over 50 milligrams and high lipophilicity had a higher risk of DILI. The talk also covered the role of reactive metabolites, drug metabolism, and the need for better predictive models to assess DILI risk accurately.

Asset Caption

Presenter: Craig Lammert

Keywords

Dr. Craig Lambert

drug-induced liver injury

DILI risk factors

reactive metabolites

predictive models