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Catalog
The Liver Meeting 2019
Distributed Hepatocytes in Liver Homeostasis and R ...
Distributed Hepatocytes in Liver Homeostasis and Regeneration
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Video Summary
Dr. Stephen Artandi, director of the Stanford Cancer Institute, presented the Hans Popper lecture on hepatocytes and telomerase in liver biology. Telomeres, protective caps at the end of chromosomes, play a crucial role in cell division and aging. Telomerase is an enzyme that adds telomere repeats to chromosome ends, preventing DNA damage and promoting cell longevity. Mutations in telomerase-related genes can lead to tissue failures, including liver cirrhosis. Telomerase is implicated in cancer as well, with mutations in the TERT gene promoter found in various cancers, including hepatocellular carcinoma (HCC). Dr. Artandi's research identified a rare subset of TERT-high hepatocytes as progenitors responsible for liver renewal and regeneration, particularly in response to injury. The TERT-high cells contribute to liver homeostasis by forming clones of hepatocytes, while also showing increased proliferation and preferentially differentiating into metabolic "worker B" hepatocytes. Genetic ablation of TERT-high cells resulted in impaired liver regeneration and fibrosis. The study suggests a distributed model for liver renewal driven by TERT-high hepatocyte progenitors, possibly serving as the cell of origin for hepatocellular carcinoma.
Asset Caption
Presenter: Steven Artandi
Keywords
Stanford Cancer Institute
Hans Popper lecture
hepatocytes
telomerase
telomeres
liver biology
TERT gene
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