The Liver Meeting 2019-Chronic Antibody-mediated Rejection: Detection and Treatment

Chronic Antibody-mediated Rejection: Detection and Treatment

Video Transcription

Video Summary

This video transcript discusses chronic antibody-mediated rejection (AMR) in liver transplant patients. The speaker emphasizes the importance of defining and diagnosing chronic AMR through specific criteria, such as histologic features, DSA in serum, and C4D staining. The video discusses the challenges and advancements in detecting C4D staining in liver tissue, as well as the association between DSA and fibrosis progression in liver allografts. The speaker also presents the CAMR score, a tool developed to predict poor outcomes in patients with chronic AMR. Prevention of chronic AMR through adherence to immunosuppression regimens and simplification of protocols is highlighted as a key strategy. The importance of targeting Class 2 antigen expression in therapeutics and the potential role of antibodies in graft injury are also discussed. Ultimately, the speaker advocates for a patient-centered approach to defining transplant success and emphasizes the need for more research to understand the mechanisms underlying chronic AMR.

Asset Caption

Presenter: Jacqueline G. O'Leary

Keywords

chronic antibody-mediated rejection

liver transplant patients

histologic features

DSA in serum

C4D staining

CAMR score

immunosuppression regimens

Class 2 antigen expression