The Liver Meeting 2019-Case-based Debate: Balancing the Costs and Benefits of Individualized Medicine* 2

Case-based Debate: Balancing the Costs and Benefits of Individualized Medicine* 2

Video Transcription

Video Summary

Dr. Lucey discusses liver transplantation for acute alcoholic hepatitis, highlighting genetic factors like the PMPLA3 gene variant. Patients with severe alcoholic hepatitis face high mortality rates and limited treatment options, with liver transplantation not commonly offered. Nutritional support and alcohol cessation play crucial roles in patient outcomes. Studies emphasize the importance of achieving total abstinence for survival. A multidisciplinary approach involving hepatologists, behavioral, and psychiatric experts is recommended for managing alcohol use disorder. Emerging therapies targeting inflammation and gut health offer hope for future interventions. Further research is needed to translate preclinical findings into human studies.

Asset Caption

Moderator: Scott Friedman
Panelist: Gyongyi Szabo

Keywords

liver transplantation

acute alcoholic hepatitis

genetic factors

PMPLA3 gene variant

alcohol use disorder