The Liver Meeting 2019-Biliary Atresia: Biomarkers of Disease and Predictors of Outcome*

Biliary Atresia: Biomarkers of Disease and Predictors of Outcome*

Video Transcription

Video Summary

The video transcript discusses a case of a two-month-old infant with jaundice and bilirubin issues leading to the diagnosis of biliary atresia. It delves into factors affecting the disease, including geographic occurrences, genetic predispositions, and diagnostic tests like direct bilirubin levels, MMP7 biomarkers, and stool color card screening. The importance of early intervention with the Kasai procedure for better outcomes is highlighted. Factors influencing survival with the native liver and potential complications in adulthood are explored, with recommendations for monitoring and interventions as needed. The lack of effective adjuvant therapies post-Kasai is also mentioned. Research on bile acid accumulation, prognostic markers, and the need for targeted therapies for biliary atresia is emphasized. Overall, it stresses the complex nature of the disease and the need for continued advancements in treatment and management strategies.

Asset Caption

Presenter: Cara Mack

Keywords

jaundice

biliary atresia

bilirubin issues

Kasai procedure

genetic predispositions