The Liver Meeting 2019-Bile Acid Signaling in Genetic Cholestatic Syndromes

Bile Acid Signaling in Genetic Cholestatic Syndromes

Video Transcription

Video Summary

The transcript provides a detailed discussion on bile acid signaling in genetic cholestatic syndromes, focusing on the liver's response to bile acid retention. The speaker discusses different aspects such as canalicular and extrahepatic obstructions, genetic diseases like ABCB11 and ABCB4 deficiencies, and the implications for liver function and pathology. The presentation highlights new research areas like intravital microscopy and stable isotope studies to understand bile acid flow and liver damage. The speaker emphasizes the importance of monitoring patients for cancer risks in certain genetic mutations and discusses the role of tight junction disruptions in cholestatic liver diseases. The talk concludes by suggesting a focus on reducing hepatic bile acid accumulation as a potential therapeutic approach.

Asset Caption

Presenter: Saul J. Karpen

Keywords

bile acid signaling

genetic cholestatic syndromes

liver response

ABCB11 deficiency

intravital microscopy

cancer risks