The Liver Meeting 2019-Beyond Traditional Supportive Care in ALF: Hemofiltration, Bio-assist Devices and Cell Transplant

Beyond Traditional Supportive Care in ALF: Hemofiltration, Bio-assist Devices and Cell Transplant

Video Transcription

Video Summary

In this talk, the speaker discusses liver failure treatment beyond traditional supportive care, focusing on hemofiltration and hepatocyte transplantation. They delve into the concept of liver regeneration, mythological origins, and the parallel processes of necrosis and regeneration in the liver. They explore various extracorporeal liver assist devices, including bio-artificial and artificial systems, detailing their mechanisms and trials. The speaker presents data from studies on charcoal hemoperfusion, ELAD, and SIRSA-BAL-RCT, highlighting the challenges and outcomes. They also discuss cell therapies, like human hepatocyte transplantation and mesenchymal stromal cells, outlining methodologies and future clinical trials. The talk underscores the ongoing quest for more effective liver support and the anticipated potential of stem cell-derived hepatocytes in liver failure treatment.

Asset Caption

Presenter: Anil Dhawan

Keywords

liver failure treatment

hemofiltration

hepatocyte transplantation

liver regeneration

extracorporeal liver assist devices

cell therapies