The Liver Meeting 2019-Basic Concepts of Liver Regeneration

Video Transcription

Video Summary

The speaker discussed the process of liver regeneration and its connection to liver disease. They highlighted how the liver is a unique organ that obsessively regenerates to maintain its optimal functions, unlike other organs. The process of liver regeneration after partial hepatectomy in rodents was explained, emphasizing the role of factors like urokinase and extracellular matrix breakdown. The importance of stellate cells in signaling during regeneration was also mentioned. The discussion touched on the role of AGF and EGF receptors in liver regeneration and how their inhibition can affect the process. Additionally, the presentation delved into the implications of chronic liver diseases on hepatocyte proliferation and the development of liver cancer. The potential role of the Hippo pathway and CD81 in controlling regeneration termination was explored as well.

Asset Caption

Presenter: George K. Michalopoulos

Keywords

liver regeneration

liver disease

organ regeneration

partial hepatectomy

stellate cells

Hippo pathway