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Catalog
The Liver Meeting 2019
Acute-on-Chronic Liver Failure: Drivers and Conseq ...
Acute-on-Chronic Liver Failure: Drivers and Consequences of Serious Acute Decompensation in Cirrhosis
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Video Transcription
Video Summary
The video transcript discusses definitions, drivers, and consequences of acute on chronic liver failure (ACLF) in both adults and children. The Asia-Pacific Association for the Study of Liver set definitions in 2009, evolving to include high short-term mortality in 2014. Differences in defining ACLF exist, with the APASL and EASL/AASLD definitions prominent. Regarding pediatric ACLF, limited data is available, with studies showing varied etiologies like Wilson's disease and autoimmune hepatitis. GI bleeding and fever are noted precipitating events. Neuroprotection approaches such as hypothermia are discussed, but data on effectiveness, especially in pediatrics, remain inconclusive. Sodium benzoate for managing hyperammonemia is mentioned, but its role in the context of ACLF needs further evaluation. The need for better definitions, more data, and standardized approaches for ACLF management, especially in pediatrics, is emphasized.
Asset Caption
Presenter: James E. Squires
Keywords
acute on chronic liver failure
ACLF
Asia-Pacific Association for the Study of Liver
EASL/AASLD definitions
pediatric ACLF
neuroprotection approaches
hyperammonemia management
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